Preface	5
	References	11
	Note Added in Proof	11
	References	12
	Contents	13
	Contents of Volume 2: Recombination and Meiosis	20
	Evolution of Models of Homologous Recombination	21
	1 Introduction	21
	2 Robin Holliday’s Remarkable Model	27
	3 Molecular Models Based on a Single Initiating DNA Lesion	33
	4 The Meselson–Radding Model (1975)	35
	5 Problems with the Meselson–Radding Model	39
	6 Alternative Ways to Initiate Recombination	40
	7 The Double Holliday DSB Repair Model of Szostak, Orr- Weaver, Rothstein and Stahl	45
	8 Identification of DNA Intermediates of Recombination	48
	9 Multiple Pathways Meiotic Recombination	55
	10 Single-Strand Annealing Causes Primarily Intrachromosomal Deletions	58
	11 Synthesis-Dependent Strand Annealing Accounts for Most Mitotic Recombination and Noncrossovers in Meiosis	59
	12 Evolution of Gene Conversion Models in the Present	65
	13 Another Major Source of Creative Thinking: Nonreciprocal Recombination in Phage .	68
	14 Re-Emergence of Old Ideas in New Guises: Break-Induced Replication	69
	References	72
	Searching for Homology by Filaments of RecA- Like Proteins	85
	1 RecA-Like Proteins and Homologous Recombination	85
	2 Sequence Effects in Homologous Recombination	92
	3 Homology Search in the Cell	94
	4 Models of Homology Search at the Molecular Level	96
	5 Homology Recognition at the Atomic Level	100
	6 Conclusion	104
	References	104
	Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates	110
	1 Introduction	111
	2 Biochemistry of Meiotic Recombination	114
	3 Conclusions and Outlook	167
	References	169
	Meiotic Chromatin: The Substrate for Recombination Initiation	184
	1 Introduction	184
	2 Double-Strand Breaks and Chromatin Structure in Saccharomyces cerevisiae	186
	3 Recombination Hotspots and Chromatin Structure in Schizosaccharomyces pombe	196
	4 Hints from Multicellular Organisms	201
	References	205
	Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic andMolecular Analysis	213
	1 S. pombe: An Excellent Model Organism for Studying Meiotic Recombination	214
	2 Overview: A Pathway for S. pombe Meiotic Recombination	215
	3 Nuclear Movement Promotes Chromosome Alignment: “ Bouquet” and “ Horsetail” Formation	217
	4 Meiosis-specific Sister Chromatid Cohesins: Behavior Change	220
	5 DSB Formation by Rec12: Preparation and Partnership	221
	6 DSB Hotspots and Coldspots: Regulating Where Recombination Occurs	226
	7 Processing of Rec12-generated DSBs: Converting a Lesion into a Recombinogenic DNA-Protein Complex	229
	8 Strand Invasion and Partner Choice	233
	9 Joint Molecule Resolution	235
	10 Mismatch Correction	237
	11 Relation of Gene Conversion and Crossing-over	238
	12 Species-specific Strategies for Ensuring, With or Without Interference, the Crossovers Required for Chromosome Segregation	239
	13 Differences Between S. pombe and S. cerevisiae Meiotic Recombination: A Reprise	240
	References	242
	Nuclear Movement Enforcing Chromosome Alignment in Fission Yeast— Meiosis Without Homolog Synapsis	249
	1 Introduction	249
	2 Alignment of Homologous Chromosomes	251
	3 Regulation of Telomere Clustering	255
	4 Regulation of Nuclear Movement	259
	5 Conclusion and Outlook	261
	References	262
	On the Origin of Meiosis in Eukaryotic Evolution: Coevolution of Meiosis and Mitosis from Feeble Beginnings	266
	1 Introduction	267
	2 A Conserved Core of Meiotic Proteins	269
	3 The Complex Eukaryotic Signature	270
	4 The Universal Trifurcation	272
	5 The RNA World Scenario	274
	6 Dynamic Implications of Eigen’s Quasi-Species Concept	278
	7 Woese’s Phase Shift at Decreasing “Evolutionary Temperature”	280
	8 Early Traits with Preadaptive Value for Meiosis	284
	9 Meiosis vs. Mitosis – Alternative Programs Responding to Different Selective Needs	288
	10 Coevolution of Meiosis and Mitosis	291
	11 Variations on the Meiotic System in the World of Protists	294
	12 Concluding Remarks	297
	References	300
	The Legacy of the Germ Line – Maintaining Sex and Life in Metazoans: Cognitive Roots of the Concept of Hierarchical Selection	306
	1 Introduction	306
	2 The Legacy of the Germ Line	308
	3 The Allmacht of Selection	329
	4 Maintaining Sex in Metazoans	336
	5 Finale	346
	References	350
	Lessons to Learn from Ancient Asexuals	357
	1 The Paradox of Sex	357
	2 What is an Ancient Asexual?	361
	3 Novel Genetic Tests – Meiosis Proteins	379
	4 Conclusions	381
	References	383
	Subject Index	393